Table 8 Predictive performance of significantly increased cervicovaginal fluid pro-inflammatory mediators and foetal fibronectin

From: Vaginal host immune-microbiome-metabolite interactions associated with spontaneous preterm birth in a predominantly white cohort

Analyte

AUC (95%CI)

Sensitivity (%)

Specificity (%)

PPV (%)

NPV (%)

+LR

−LR

Criterion

TNFR1a

0.88 (0.56–0.99)

75.0

100.0

100.0

88.9

–

0.25

≤11.13

GTP1/GTP2 ratio

CXCL10

0.68 (0.53–0.82)

42.86

93.6

75.0

78.4

6.64

0.61

>1.194

CXCL10 + FFN

0.74 (0.58–0.86)

64.29

79.31

60.0

82.1

3.11

0.45

>0.36

  1. None of the detected chemokines/cytokines differed between term- vs. preterm-delivered women at GTP1.
  2. AUC area under the ROC curve; Criterion (or cut-off), concentration that indicates the likelihood of spontaneous preterm birth. CXCL10 C-X-C motif chemokine ligand 10 (CXCL10) or Interferon gamma-induced protein 10 (IP10), FFN foetal fibronectin, GTP gestational time point, TNFR1 Tumour necrosis factor receptor 1, NPV negative predictive value, PPV positive predictive value, −LR negative likelihood ratio, +LR positive likelihood ratio.
  3. aTNFR1 was the only analyte that differed significantly between term- vs. preterm-delivered women at GTP2.
Back to article page