Fig. 2: Membrane vesicles ameliorate colitis.

a Schematic of the mouse experiment. b Body weight of mice as a percent of the initial weight recorded at day 1. Points represent the mean ± SEM. Healthy group n = 10, colitis control n = 10, ∆hemB MVs n = 15, and wt MVs n = 15. c Compiled percent of initial weight for each mouse from days 2 to 8. Healthy n = 70, colitis control n = 70, ∆hemB MVs n = 105, wt MVs n = 105. Line and error bars represent the mean ± SEM. Significance determined using Kruskal-Wallis test with Dunn’s multiple comparisons test. Adjusted p values were as follows, ***p = 0.0005, ****p < 0.0001. d Length of colon distal of the cecum. Healthy n = 10, colitis control n = 10, ∆hemB MVs n = 14, wt MVs n = 15. Bars represent the mean ± SEM. Significance determined using one-way ANOVA with Tukey’s multiple comparisons test. Adjusted p values were as follows, **p = 0.0021, ***p < 0.001, ****p < 0.0001.