Fig. 1: Global microbial composition of endometrial cancer patients differs compared to benign gynecologic conditions.

The vaginal microbiome is significantly different between patients diagnosed with endometrial cancer and benign conditions. A Taxa barplot of genera in the gut and vaginal microbiomes across disease groups: Benign gynecologic conditions (Benign), Endometrial hyperplasia (Hyperplasia), Endometrial cancer. B Faith’s PD is significantly different between patients with EC and Benign conditions (Kruskal-Wallis: H: 31.784899, p value: 1.722266e–08, q-value:5.166797e–08) and nearly significantly different between Hyperplasia and Benign individuals (Kruskal-Wallis: H: 3.461674, p value: 6.280670e-02, q-value: 9.421005e–02). C Pielou’s Evenness is also significantly different between EC and benign conditions (Kruskal-Wallis: H: 18.779978, p value: 0.000015, q-value: 0.000044). D There is a significant difference in Lactobacillus relative abundance between benign and endometrial cancer individuals (Mann–Whitney-U: q-value: 3.162e–04). E There is also a significant difference between grade 1/2 endometrioid cancer (EEC) and other endometrial cancer subtypes (Other EC) (Mann–Whitney-U: q-value: 3.087e–02).