Fig. 3: Overview of the key gut metabolic pathways in the pathogenesis of NAFLD. | npj Biofilms and Microbiomes

Fig. 3: Overview of the key gut metabolic pathways in the pathogenesis of NAFLD.

From: Targeted metabolomics reveals bioactive inflammatory mediators from gut into blood circulation in children with NAFLD

Fig. 3

Pathway enrichment plots of fecal (A) and plasma (B) shown the pathway enrichment analysis by KEGG for metabolites. The pathway enrichment analysis result takes KEGG pathway as the unit, and the hypergeometric test is applied to find the pathway that is enriched in the differential metabolites against the background of all identified metabolites. Pathway enrichment analysis can determine the most important metabolic pathways and signal transduction pathways involved in the differential metabolites. An overview plot shown the key metabolic pathways in the pathogenesis of NAFLD (C). Boxplots show levels of these metabolites in the plasma samples at different stages. AAs amino acids, PCs Phosphatidylcholines, BCAAs branched-chain amino acids, ChoE cholesterol esters, CoA coenzyme A, G3P glyceraldehyde 3-phosphate, GNG gluconeogenesis, CKs Inflammatory cytokines, ROS reactive oxygen species, SFA saturated fatty acid, TCA tricarboxylic acid. NAFL nonalcoholic fatty liver, NASH non-alcoholic steatohepatitis.

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