Fig. 4: Metabolites discriminates disease severity and association of mediators with markers of inflammation, glycolipid metabolism and liver function.

A heatmap of plasma (A) shown the correlation between selected gut metabolites with glycolipid metabolism, liver function and inflammatory factors indices. Red color represents positive correlation, blue color represents negative correlation. Bar chart (B) show the qRT-PCR of differentially relative expressed mRNAs of liver function and inflammation produced by THLE-3 under different treatments, C control group, NAFL nonalcoholic fatty liver, NASH non-alcoholic steatohepatitis. p < 0.05 was considered statistically significant. *p < 0.05; **p < 0.01.