Fig. 8: In vivo efficacy of trisindoline derivative 3e. | npj Biofilms and Microbiomes

Fig. 8: In vivo efficacy of trisindoline derivative 3e.

From: Synthesis and antibacterial evaluation of trisindolines against methicillin-resistant Staphylococcus aureus targeting cell membrane

Fig. 8

A Schematic representation depicting MRSA-induced Systemic infection model (B–E). Therapeutic efficacy of compound 3e in MRSA-induced mouse systemic infection model depicted eradication potential in vivo, computed as reduction in the MRSA CFU in major organs like kidneys, liver, spleen and lungs respectively. F H&E stained histopathology of (a) Liver (b) Lung (c) Spleen and (d) Kidneys (x100 magnification). Infection control group mice showed vacuolar degeneration of hepatocytes, congestion, emphysema, denudation of alveolar epithelium, and focal infiltration of mononuclear cells in the lungs (arrow). Lymphoid hyperplasia of the spleen and vacuolar degeneration of the kidneys are evident. The treated groups and standards had a mild degree of congestion in the lungs and cell swelling in the kidneys and spleen.

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