Table 2 MIC values of the active trisindolines against MDR clinical isolates of S. aureus

From: Synthesis and antibacterial evaluation of trisindolines against methicillin-resistant Staphylococcus aureus targeting cell membrane

S. No.

MDR-clinical isolates

MIC of the active Trisindolines, µg/ml

3b

3c

3d

3e

3g

3l

3n

3o

1

SA-01

4.9

2.6

2.6

6.5

2.7

44.8

2.7

11.6

2

SA-02

19.9

43

>43

51.7

44.2

44.8

44.4

23.2

3

SA-03

4.9

1.3

2.6

6.5

5.2

5.6

2.7

5.8

4

SA-04

>39.8

43

>43

>51.7

>44.2

>44.8

>44.4

>46.4

5

SA-05

>39.8

>43

>43

>51.7

>44.2

>44.8

>44.4

>46.4

6

SA-06

4.9

1.3

5.4

1.6

5.2

5.6

2.7

2.8

7

SA-07

4.9

0.6

0.6

3.2

0.6

5.6

0.6

5.8

8

SA-08

>39.8

>43

>43

>51.7

>44.2

>44.8

>44.4

>46.4

9

SA-09

>39.8

43

43

25.8

44.2

44.8

44.4

23.2

10

SA-10

>39.8

>43

>43

>51.7

>44.2

>44.8

>44.4

>46.4

11

SA-11

4.9

0.6

0.6

1.6

0.6

5.6

0.6

2.8

12

SA-12

2.4

1.3

1.3

6.5

5.2

5.6

11.1

5.8

13

SA-13

39.8

21.5

21.5

51.7

44.2

44.8

44.4

46.4

14

SA-14

19.9

21.5

21.5

25.8

22.1

22.4

22.2

11.6

15

SA-15

>39.8

>43

>43

>51.7

>44.2

>44.8

>44.4

>46.4

16

SA-16

4.9

0.6

1.3

6.5

0.6

5.6

0.6

2.8

17

SA-17

4.9

0.6

5.4

3.2

0.6

2.7

0.6

5.8

18

SA-18

19.9

43

21.5

51.7

44.2

>44.8

>44.4

23.2

19

SA-19

19.9

21.5

43

25.8

44.2

22.4

44.4

46.4

20

SA-20

>39.8

21.5

21.5

51.7

44.2

22.4

22.2

23.2

21

SA-21

39.8

21.5

43

25.8

44.2

22.4

22.2

23.2