Table 3 CC50 values and selectivity indexes (SI = CC50/MICs) of potential hits against different mammalian cell lines (RAW 264.7 and HEK 293) and HC50 values of trisindoline derivatives towards red blood cells

From: Synthesis and antibacterial evaluation of trisindolines against methicillin-resistant Staphylococcus aureus targeting cell membrane

Entry

RAW 264.7

HEK293

RBCs

CC50, µM

SIa

CC50, µM

SIb

HC50, µM

3b

69.04

11.13

85.75

13.83

>200

3c

49.5

15.96

84.98

27.41

>200

3d

101.3

32.67

>200

ND

140.6

3e

47.42

31.61

56.32

37.54

61.4

3g

81.88

13.20

95.24

15.36

>200

3l

97.98

31.60

>200

ND

45.2

3n

99.45

32.08

196.9

63.51

>200

3o

75.06

24.21

93.77

30.24

201.4

  1. ND not determined.
  2. aSelectivity index (SI) against RAW 264.7.
  3. bSelectivity index (SI) against HEK 293.
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