Fig. 6: The protein expression and distribution in the preoptic anterior hypothalamus of the Control and Torpor-like mice.
From: Intestinal bacteria trigger a hibernation-like state in homotherms via the gut-brain axis
A–D Representative immunofluorescence images (left) and protein densities (right) of TRPV1, TRPM8, CerS, and GM2A in the POA (preoptic anterior hypothalamus) of Control and Torpor-like mice. E The relationship between of POA and PH (posterior hypothalamus). In the bar graphs, the green and pink bars indicate the Control (n = 5) and Torpor-like (n = 5) groups, respectively. All bar graphs depict means ± standard errors of the mean. Two-tailed unpaired t-tests (A–D) was used to detect statistical significance. *p < 0.05, **p < 0.01, ***p < 0.001. CerS ceramide synthase, GM2A ganglioside activator, TPRM8 transient receptor potential cation channel, subfamily member 8, TRPV1 transient receptor potential vanilloid 1, MPA medial preoptic area, VLPO ventrolateral preoptic nucleus, MPO medial preoptic nucleus, Pe periventricular nucleus, VMPO ventromedial preoptic nucleus, LPO lateral preoptic area, DMH dorsomedial hypothalamus, ARC arcuate nucleus, LH lateral hypothalamus, VMH ventromedial hypothalamus, TU olfactory tubercle.
