Table 4 Twelve-month change in gene expression (unsupervised) according to vitamin D repletion status (25(OH)D</≥32 ng/mL) among women randomized to 2000 IU vitamin D

From: Gene expression in breast and adipose tissue after 12 months of weight loss and vitamin D supplementation in postmenopausal women

Gene

All

<32 ng/ml at 12 mo

≥32 ng/ml at 12 mo

p*

AB

N = 28

N = 11

N = 17

 

VDR

−9.8%

−16.3%

−5.9%

0.611

CYP19A1

−17.0%

−7.6%

−24.1%

0.956

PPARg

11.6%

10.0%

12.8%

0.239

Adipoq

5.7%

15.1%

−0.6%

0.068

MCP-1

16.1%

12.3%

19.2%

0.084

RPFNA

N = 29

N = 12

N = 17

 

VDR

−9.8%

−6.8%

−11.2%

0.435

CYP19A1

33.0%

104.1%

−5.3%

0.422

PPARg

35.1%

45.8%

29.0%

0.351

Adipoq

16.4%

15.4%

17.0%

0.367

MCP-1

21.0%

61.2%

−1.6%

0.015

  1. AB adipose biopsy, RPFNA random periareolar fine needle aspiration
  2. * Based on binary 25(OH)D serum level, adjusted for age, race, baseline serum 25(OH)D, total vitamin D intake (diet + supplement) and sun exposure (h/d)
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