Fig. 2 | npj Breast Cancer

Fig. 2

From: Phyllodes tumors with and without fibroadenoma-like areas display distinct genomic features and may evolve through distinct pathways

Fig. 2

Repertoire of somatic genetic alterations identified in phyllodes tumors (PTs) with fibroadenoma (FA)-like areas and PTs without FA-like areas. Heatmap illustrating non-synonymous somatic mutations, gene amplifications and homozygous deletions in PTs with FA-like areas (n = 7) and PTs without FA-like areas (n = 9), identified by targeted capture massively parallel sequencing (MSK-IMPACT). Cases are shown in columns and genes are represented in rows. Only genetic alterations affecting the 227 genes present in both targeted capture panels used in this study are shown. The different genetic alterations are color-coded according to the legend. Loss of heterozygosity of a mutated gene is indicated by a diagonal bar. Promoter SNVs are shown with a triangle. MED12 exon 2 mutations are indicated by an asterix; BOPT3 harbored a MED12 mutation in exon 4. OncoKB level 3A (breast cancer) is indicated by a circle

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