Table 1 Baseline patient, tumor, and treatment characteristics

From: Phase II study of ruxolitinib, a selective JAK1/2 inhibitor, in patients with metastatic triple-negative breast cancer

Characteristics

All (n = 21)

 

No. of patients (%)

Age, years

Median (range)

51 (36–72)

Race

White

18 (86%)

Black or African-American

1 (5%)

Asian

1 (5%)

Other

1 (5%)

ECOG PS at baseline

0

9 (43%)

1

11 (52%)

2

1 (5%)

Disease-free interval

<2 years

16 (76%)

>2 years

4 (19%)

Stage IV disease at diagnosis

1 (5%)

Inflammatory breast cancera

1 (5%)

Adjuvant or neoadjuvant chemotherapy

Adjuvant or neoadjuvant anthracycline

17 (81%)

Adjuvant or neoadjuvant taxane

16 (76%)

Lines of chemotherapy for metastasis or recurrence

Median (range)

2 (1–8)

None

0 (0%)

1 line

6 (29%)

2 lines

5 (24%)

3+ lines

10 (48%)

Prior chemotherapy for metastasis or recurrence

Capecitabine

9 (43%)

Platinum salt

12 (57%)

Eribulin

5 (24%)

  1. aThe single patient with inflammatory breast cancer enrolled had ER-negative, PR-negative, and HER2-negative disease