Fig. 3

Survival analysis of Nf1^IF vs. Nf1^PS reveals distinct effects of Nf1 deficiency on tumor onset and survival. Survival analysis was performed on Nf1^IF (n = 35) vs. Nf1^PS (n = 24) in the Nf1^IF-57/+, Nf1^IF-57/PS-8, Nf1^IF-54/PS-11 lines. Kaplan–Meier plots of a) tumor onset, b disease-specific survival, and c overall survival are shown. d Tumor burden of em3-Nf1^IF-57/+ compared to em3-Nf1^PS-8 rats. e Overall survival analysis of em2 and em3 lines harboring the Nf1^IF-57/+ indel showed a discrepancy in survival. f Tumor onset of em3-Nf1^IF-57/+ compared to em3-Nf1^PS-8 rats. All animals in this study died of mammary tumor progression