Fig. 2 | npj Breast Cancer

Fig. 2

From: The phosphatase PPM1A inhibits triple negative breast cancer growth by blocking cell cycle progression

Fig. 2

PPM1A is preferentially deleted in ER-negative Breast Cancer. a Comparison of phosphatase deletions in ER-negative and ER-positive breast cancer in the METABRIC dataset. Both heterozygous and homozygous deletions are collectively termed “deletion.” b PPM1A is preferentially deleted in ER-negative, compared to ER-positive, breast cancer. c PPM1A is most frequently deleted in the basal Pam50 subtype. d PPM1A mRNA expression correlates with somatic alteration and PAM50 classification. The violin plot shows median (dashed line) and quartiles (dotted lines), and p-values were calculated using Student’s t-test (****p < 0.0001)

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