Fig. 5
Mapper analysis of the 290 GTEx normal mammary tissue samples using the basal–luminal score as filter function. (Above) Along the PAM50 gene set, using the basal–luminal score as filter function. (Below) The same sample set, in the same order, showing the expression of the marker genes of Santagata et al.,5 which define the normal mammary cell-type classification proposed by those authors. A substantial group displays the Myo/Luminal/Her2 phenotype. According to the Santagata et al. classification, these samples are primarily a combination of the myoepithelial type M2 (TP63+/KRT5+) and the luminal–epithelial type L7 (VDR+/KRT5+)
