Fig. 5 | npj Breast Cancer

Fig. 5

From: Suppression of FOXM1 activities and breast cancer growth in vitro and in vivo by a new class of compounds

Fig. 5

Pharmacokinetics and half-lives of compounds in mice after s.c. or oral administration of amine compounds and their respective methiodide salts. Pairs are NB-55 and NB-63; NB-65 and NB-68; NB-70 and NB-71; NB-72 and NB-73; and NB-51 and NB-115. PK was studied after single dose administration via s.c. injection or oral gavage at the doses indicated. Multiple plasma samples were collected from each mouse (n = 4) over the course of 48 h after compound was administered. Compounds were quantified using LC-MS/MS. The data were fitted to a non-compartment PK model (error bars are ± SD).

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