Table 1 Patients’ demographic, clinicopathological characteristics, treatment, and the patterns of distant metastasis (N = 8725).
From: Incorporation of biologic factors for the staging of de novo stage IV breast cancer
Variables | N (%) |
|---|---|
Age (years) | |
Mean ± SD (range) | 59.7 ± 13.9 (19–103) |
Race/ethnicity | |
Non-Hispanic White | 5647 (64.7) |
Non-Hispanic Black | 1467 (16.8) |
Hispanic (All Races) | 941 (10.8) |
Other | 658 (7.5) |
Unknown | 12 (0.1) |
Grade | |
G1 | 743 (8.5) |
G2 | 3704 (42.5) |
G3 | 4278 (49.0) |
Histological subtypes | |
Infiltrating ductal carcinoma | 7244 (83.0) |
Infiltrating lobular carcinoma | 875 (10.0) |
Other | 606 (6.9) |
Tumor stage | |
T1 | 1294 (14.8) |
T2 | 2968 (34.0) |
T3 | 1550 (17.8) |
T4 | 2913 (33.4) |
Nodal stage | |
N0 | 2098 (24.0) |
N1 | 3914 (44.9) |
N2 | 1183 (13.6) |
N3 | 1530 (17.5) |
Hormone receptor status | |
ER+ and PR+ | 5400 (61.9) |
ER+ or PR+ | 1483 (17.0) |
ER− and PR− | 1842 (21.1) |
HER2 status | |
Negative | 6789 (77.8) |
Positive | 1936 (22.2) |
Surgery | |
No | 4897 (56.1) |
Yes | 3793 (43.5) |
Unknown | 35 (0.4) |
Radiotherapy | |
No | 5327 (61.1) |
Yes | 3166 (36.3) |
Unknown | 232 (2.7) |
Chemotherapy | |
No | 3104 (35.6) |
Yes | 5621 (64.4) |
Bone metastasis | |
No | 3164 (36.3) |
Yes | 5561 (63.7) |
Brain metastasis | |
No | 8189 (93.9) |
Yes | 536 (6.1) |
Liver metastasis | |
No | 6636 (76.1) |
Yes | 2089 (23.9) |
Lung metastasis | |
No | 6174 (70.8) |
Yes | 2551 (29.2) |
Other metastatic sites | |
No | 7497 (85.9) |
Yes | 1228 (14.1) |
Number of metastatic sites (n = 7497)a | |
1 | 4963 (66.2) |
2 | 1908 (25.5) |
3 | 546 (7.3) |
4 | 80 (1.1) |
