Fig. 1: Breast lobular composition returns to pre-pregnant like state by three months post-wean. | npj Breast Cancer

Fig. 1: Breast lobular composition returns to pre-pregnant like state by three months post-wean.

From: Characterization of weaning-induced breast involution in women: implications for young women’s breast cancer

Fig. 1

a Representative H&E images of biopsies from each reproductive group: nulliparous, lactation, and 0.5, 1, 2, 3, 4–6, >12 months post-wean. b Quantification of the average lobular composition by lobular subtype for each group: nulliparous (N) n = 17, lactation (L) n = 20, and 0.5 (n = 18), 1 (n = 15), 2 (n = 11), 3 (n = 11), 4–6 (n = 4), 12–24 months post-wean (n = 12). In this chort, type 1 average 15 acini/lobule, type 2 average 35 acini per lobule, type 3 average 112 acini/lobule, and type 4 average 112 acini/lobule with flattened epithelium and large acinar lumen. c Lobular composition by case shows heterogeneity within each reproductive group. d Representative H&E images show lobular heterogeneity observed in the lactation group. (****P ≤ 0.0001, **P ≤ 0.01, scale bar = 100 µm).

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