Fig. 4: Biological validation of automated DCIS detection using CK5 immunohistochemistry.
From: Unmasking the immune microecology of ductal carcinoma in situ with deep learning
a An example showing CK5 IHC image where DCIS regions were annotated by hand following the CK5 expression pattern, indicated by green contour. b Segmented H&E image with DCIS regions marked in blue contour by IM-Net for the same sample. c Quantitative assessment of the IHC-H&E correlation between H&E-based automated DCIS detection result and hand annotations on IHC using an estimated number of DCIS. d Quantitative assessment of the IHC-H&E correlation between H&E-based automated DCIS detection result and hand annotations on IHC using an estimated area of DCIS.
