Fig. 4: Heterogeneity in sTIL distribution as a cause of variation in sTIL assessment in breast cancer. | npj Breast Cancer

Fig. 4: Heterogeneity in sTIL distribution as a cause of variation in sTIL assessment in breast cancer.

From: Pitfalls in assessing stromal tumor infiltrating lymphocytes (sTILs) in breast cancer

Fig. 4: Heterogeneity in sTIL distribution as a cause of variation in sTIL assessment in breast cancer.The alternative text for this image may have been generated using AI.

Different examples of heterogeneity include a increased sTILs at the leading edge (blue arrow) compared to the central tumor (yellow arrow); b marked heterogeneity in sTIL density within the tumor; and c variably spaced apart clusters of cancer cells with a dense tight lymphocytic infiltrate separated by collagenous stroma with sparse infiltrate.

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