Fig. 1: Full distributions for measures of age acceleration in peripheral blood from pre- to post-treatment. | npj Breast Cancer

Fig. 1: Full distributions for measures of age acceleration in peripheral blood from pre- to post-treatment.

From: The acute effects of adjuvant radiation and chemotherapy on peripheral blood epigenetic age in early stage breast cancer patients

Fig. 1

In addition to intrinsic (IEAA, a), extrinsic (EEAA, b), phenotypic (PEAA, c), and Grim (GEAA, d) measures of age-acceleration, age-adjusted estimates of senescent cytotoxic T lymphocytes (e) and naive T lymphocytes (f) are shown for the full sample. Our repeated measures ANOVA analysis revealed significant increases in EEAA (p = 0.0021), PEAA (p = 0.015), GEAA (P = 3.2 × 10−6), and age-adjusted estimates of senescent cytotoxic T lymphocytes (p = 0.038). Age-adjusted estimates of naive T lymphocytes decreased after treatment (p = 2.2 × 10−5). There was no significant change in IEAA with treatment (p = 0.83). Supplementary Fig. 2 reveals boxplots for each of these age acceleration measures and estimated cell counts, separated by treatment type.

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