Table 5 Summary of loss of heterozygosity and additional somatic truncating mutations detected in genes.
Gene | Number of germline mutant alleles | Number of tumor analyzed | LOH | AST | ND | Ratio of LOH or AST |
|---|---|---|---|---|---|---|
PALB2 | 7 | 5 | 1 | 4 | 0 | 5/5 (100%) |
ATM | 6 | 3 | 2 | 0 | 1 | 2/3 (67%) |
RAD51D | 4 | 3 | 1 | 0 | 2 | 1/3 (33%) |
BARD1 | 5 | 2 | 1 | 0 | 1 | 1/2 (50%) |
BRIP1 | 3 | 2 | 1 | 0 | 1 | 1/2 (50%) |
RAD51C | 3 | 2 | 1 | 0 | 1 | 1/2 (50%) |
NF1 | 1 | 1 | 1 | 0 | 0 | 1/1 (100%) |
BLM | 4 | 1 | 0 | 0 | 1 | 0/1 (0%) |
FANCM | 2 | 1 | 0 | 0 | 1 | 0/1 (0%) |
RAD50 | 1 | 1 | 0 | 0 | 1 | 0/1 (0%) |
CHEK2 | 1 | 1 | 0 | 0 | 1 | 0/1 (0%) |
RECQL | 1 | 0 | 0 | 0 | 0 | 0/0 (NA) |
Total | 38 | 22 | 8 | 4 | 10 | 12/22 (54.5%) |
