Fig. 6: Association of IGHA2 mRNA with prognosis upon adjustment for immune cell metagenes. | npj Breast Cancer

Fig. 6: Association of IGHA2 mRNA with prognosis upon adjustment for immune cell metagenes.

From: Prognostic implications of the expression levels of different immunoglobulin heavy chain-encoding RNAs in early breast cancer

Fig. 6: Association of IGHA2 mRNA with prognosis upon adjustment for immune cell metagenes.

Multivariable Cox proportional hazards models of all cases and limited to basal-like case were performed for the SCAN-B cohort adjusting for different immune metagenes. The metagenes, indicated to the left in the figure, were generated using the microenvironment cell population Counter as for Fig. 1, as the mean log2 expression of mRNA-encoding cytokines specific for Th cells38, or utilizing the log2 expression of FOXP3. The models were also adjusted for tumor size, lymph node status, patient age and chemotherapy treatment. For the model using all cases, adjustment was also done for PAM50 subgroup. The hazards ratios with 95% confidence interval for normalized log2 IGHA2 mRNA expression are shown in the figure.

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