Fig. 3: Comparison between HRD scores derived from arrays and WGS, and other genomic features.
From: Using whole-genome sequencing data to derive the homologous recombination deficiency scores
a Scatterplot of array- (Y-axis) and WGS- (X-axis) derived HRD scores; the dashed black line indicates the HRD score threshold of 42, the line of equality (where array is equal to WGS data) is represented by a blue dashed line (for reference) and cases are labelled according to their germline BRCA status obtained from Nones et al.12 (see legend to Fig. 1). The five cases differentially classified are labelled and marked with triangles. b Circos plots of tumours FBC050798, FBC020636, FBC060411, FBC070086 and FBC013587, those where array and WGS-derived HRD scores disagreed when considering the threshold of 42 for HR status. The circos plots display copy number and B-allele frequency (outer rings) and somatic structural variants (SVs) are represented by lines in the inner ring. Colour of the lines represent SV types. c Circos plots for representative tumours classified definitively as HR proficient (HRD = 8) or deficient (HRD = 99), for reference.
