Table 2 Correlation between Ki67 labeling indexes/tumor grade and 21-gene recurrence score as categorical variables in women age ≥ 50.
From: Systematic evaluation of scoring methods for Ki67 as a surrogate for 21-gene recurrence score
Variable | RS category based on TAILORx | Total | χ2 | P value | |||
|---|---|---|---|---|---|---|---|
0–15 | 16–19 | 20–25 | >25 | ||||
Ki67 hotspot | |||||||
<10 | 4 | 4 | 3 | 1 | 12 (13.8%) | 24.71 | 0.016 |
<20 | 12 | 3 | 0 | 0 | 15 (17.2%) | ||
<30 | 14 | 3 | 3 | 2 | 22 (25.3%) | ||
<40 | 6 | 2 | 3 | 5 | 16 (18.4%) | ||
≥40 | 4 | 5 | 7 | 6 | 22 (25.3%) | ||
Ki67 average | |||||||
<10 | 27 | 10 | 5 | 2 | 44 (50.6%) | 30.49 | 0.0023 |
<20 | 12 | 5 | 6 | 6 | 29 (33.3%) | ||
<30 | 1 | 2 | 4 | 2 | 9 (10.3%) | ||
<40 | 0 | 0 | 1 | 3 | 4 (4.6%) | ||
≥40 | 0 | 0 | 0 | 1 | 1(1.1%) | ||
Ki67 hottest spot | |||||||
<10 | 3 | 4 | 2 | 1 | 10 (11.5%) | 21.41 | 0.0447 |
<20 | 8 | 3 | 1 | 0 | 12 (13.7%) | ||
<30 | 15 | 2 | 2 | 2 | 21 (24.1%) | ||
<40 | 9 | 3 | 4 | 3 | 19 (21.8%) | ||
≥40 | 5 | 5 | 7 | 8 | 25 (28.7%) | ||
Grade | |||||||
1 | 9 | 4 | 0 | 2 | 15 (17.2%) | 17.80 | 0.0067 |
2 | 29 | 13 | 11 | 7 | 60 (69.0%) | ||
3 | 2 | 0 | 5 | 5 | 12 (13.8%) | ||
Grade and Ki67 combined | |||||||
Low risk (grade 1 or hotspot < 20) | 23 | 8 | 3 | 2 | 36 (41.4%) | 12.13 | 0.0069 |
High risk (others) | 17 | 9 | 13 | 12 | 51 (58.6%) | ||
Total | 40 (46.0%) | 17 (19.5%) | 16 (18.4%) | 14 (16.1%) | 87 | ||
