Table 3 Pattern of invasive disease-free survival events according to hormone receptor status.

From: Clinical behavior and outcomes of breast cancer in young women with germline BRCA pathogenic variants

 

Hormone receptor-positive N (%) n = 547

Hormone receptor-negative N (%) n = 689

P valuea

Follow-up, median (IQR)

7.8 (5.8–10.6)

7.9 (5.5–10.6)

1.00

No events

329 (60.1)

425 (61.7)

0.91

Loco-regional recurrence

45 (8.2)

45 (6.5)

0.28

Distant recurrence +/− loco-regional recurrence

88 (16.1)

62 (9.0)

<0.001

Second primary malignancy

15 (2.8)

28 (4.0)

0.18

 Ovarian cancer

7 (1.3)

12 (1.7)

 

 Other

6 (1.1)

5 (0.7)

 

 Missing

2 (0.4)

11 (1.6)

 

Second primary breast cancer

66 (12.1)

123 (17.9)

0.005

Death without any disease-free survival event

4 (0.7)

6 (0.9)

0.75

  1. IQR interquartile range.
  2. aP-values for time-dependent events estimated by means of the Log-rank test.