Table 1 Baseline patient characteristics in the entire cohort and by receipt of radiation therapy.

From: De-escalation of radiation therapy in patients with stage I, node-negative, HER2-positive breast cancer

 

Entire Cohort (N = 6897)

Had RT (N = 6388)

RT omission (N = 509)

p Value

Age

Mean (standard deviation)

59.6 (10.4)

59.2 (10.2)

64.0 (11.6)

<0.0001

≥70 yrs, N (%)

1204 (17.5%)

996 (15.6%)

208 (40.9%)

<0.0001

Comorbidities

   

<0.0001

0

5845 (84.8%)

5445 (85.2%)

400 (78.6%)

 

≥1

1052 (15.2%)

943 (14.8%)

109 (21.4%)

 

Laterality

   

0.1962

Left

3564 (51.7%)

3315 (51.9%)

249 (48.9%)

 

Right

3333 (48.3%)

3073 (48.1%)

260 (51.1%)

 

Hormone status

   

0.4174

ER+ or PR+

5264 (76.3%)

4883 (76.4%)

381 (74.9%)

 

ER−/PR−

1633 (23.7%)

1505 (23.6%)

128 (25.1%)

 

Tumor size

   

0.2204

≤1 cm

2504 (36.3%)

2332 (36.5%)

172 (33.8%)

 

>1–2 cm

4393 (63.7%)

4056 (63.5%)

337 (66.2%)

 

Tumor grade

   

0.3196

Grade 3

3346 (48.5%)

3088 (48.3%)

258 (50.7%)

 

Grade 1–2

3277 (47.5%)

3050 (47.8%)

227 (44.6%)

 

Unknown

274 (4.0%)

250 (3.9%)

24 (8.8%)

 

Facility type

   

0.3496

Academic

2224 (32.3%)

2074 (32.5%)

150 (29.5%)

 

Other

4499 (65.2%)

4152 (65.0%)

347 (7.7%)

 

Unknown

174 (2.5%)

162 (2.5%)

12 (6.9%)

 

Race/ethnicity

   

0.3428

Non-Hispanic White

5459 (79.2%)

5063 (79.3%)

396 (77.8%)

 

Non-Hispanic Black

765 (11.1%)

714 (11.2%)

51 (10.0%)

 

Hispanic

331 (4.8%)

300 (4.7%)

31 (6.1%)

 

Non-Hispanic Other

299 (4.3%)

273 (4.2%)

26 (5.1%)

 

Unknown

43 (0.6%)

38 (0.6%)

5 (1.0%)

 

Income status

   

0.0016

<$46,000/yr

3432 (49.8%)

3145 (49.2%)

287 (56.4%)

 

≥$46,000/yr

3269 (47.4%)

3066 (48.0%)

203 (39.9%)

 

Unknown

196 (2.8%)

177 (2.8%)

19 (3.7%)

 

No HSD

   

0.0467

≥20%

2196 (31.8%)

2014 (31.5%)

182 (35.8%)

 

<20%

4505 (65.3%)

4197 (65.7%)

308 (60.5%)

 

Unknown

196 (2.8%)

177 (2.8%)

19 (3.7%)

 

Distance to facility

   

0.8743

≥8.9 miles

3465 (50.2%)

3211 (50.3%)

254 (49.9%)

 

<8.9 miles

3432 (49.8%)

3177 (49.7%)

255 (50.1%)

 

Chemotherapy

   

0.0022

Single-agent

2341 (33.9%)

2140 (33.5%)

201 (39.5%)

 

Multi-agent

4449 (64.5%)

4154 (65.0%)

295 (58.0%)

 

Not specified

107 (1.6%)

94 (1.5%)

13 (2.5%)

 

Receipt of ETa

   

<0.0001

Yes

4520 (85.9%)

4338 (88.8%)

182 (47.8%)

 

No

744 (14.1%)

545 (11.2%)

199 (52.2%)

 
  1. RT radiation therapy, NHW non-Hispanic white, NHB non-Hispanic Black, HSD high-school diploma.
  2. aOnly in patients with ER+ and/or PR+ disease.