Table 4 Multivariate Cox regression analysis for overall survival by hormone-receptor status. Hazards ratio > 1 implies the factor is associated with increased risk of death.
ER−/PR− (N = 1633) [HR, 95% CI, p value] | Hormone-sensitive (N = 5264) [HR, 95% CI, p value] | |
|---|---|---|
No RT vs. RT | 4.20 (1.93–9.11), p = 0.0003 | 5.72 (3.73–8.76), p < 0.0001 |
No ET vs. ET | N/A | 3.14 (2.07–4.77), p < 0.0001 |
Age | ||
≥70 yrs vs. <70 | 2.24 (1.07–4.66), p = 0.0317 | 2.01 (1.34–3.00), p = 0.0007 |
Comorbidities | ||
0 | Reference | Reference |
≥1 | 1.09 (0.48–2.50), p = 0.8389 | 1.57 (1.07–2.46), p = 0.0225 |
Tumor size | ||
≤1 cm | Reference | Reference |
>1–2 cm | 1.40 (0.68–2.88), p = 0.3556 | 1.51 (0.94–2.13), p = 0.0969 |
Tumor grade | ||
Grade 1–2 | Reference | Reference |
Grade 3 | 1.13 (0.53–2.42), p = 0.7569 | 1.33 (0.92–1.94), p = 0.1319 |
Unknown | 0.59 (0.07–4.78), p = 0.6231 | 1.20 (0.48–3.02), p = 0.7013 |
Facility type | ||
Other | Reference | Reference |
Academic | 0.86 (0.42–1.75), p = 0.6709 | 0.76 (0.50–1.72), p = 0.1862 |
Unknown | 0.00 (0.00–0.00), p = 0.9862 | 0.23 (0.03–1.72), p = 0.1530 |
No HSD | ||
<20% | Reference | Reference |
≥20% | 1.66 (0.72–3.82), p = 0.2355 | 1.15 (0.74–1.77), p = 0.5349 |
Unknown | 1.20 (0.16–9.14), p = 0.8604 | 0.47 (0.11–1.97), p = 0.2986 |
Income status | ||
≥$46,000/yr | Reference | Reference |
<$46,000/yr | 0.78 (0.34–1.79), p = 0.5553 | 1.41 (0.92–2.18), p = 0.1191 |
Unknown | 1.15 (0.15–8.73), p = 0.8940 | 0.46 (0.11–1.94), p = 0.2914 |
Chemotherapy | ||
Single-agent | Reference | Reference |
Multi-agent | 0.76 (0.36–1.60), p = 0.4678 | 0.69 (0.47–1.02), p = 0.0655 |
Not specified | 1.34 (0.17–10.61), p = 0.7792 | 0.93 (0.22–3.87), p = 0.9220 |
