Table 6 Cox regression analysis of overall survival for the patients that did not receive radiation therapy.

From: De-escalation of radiation therapy in patients with stage I, node-negative, HER2-positive breast cancer

 

Univariate analysis [HR, 95% CI, p value]

Multivariate analysis [HR, 95% CI, p value]

Age

≥70 yrs vs. <70

1.41 (0.85–2.33), p = 0.1876

1.23 (0.73–2.07), p = 0.4352

Comorbidities

0

Reference

Reference

≥1

1.47 (0.84–2.58), p = 0.1800

1.48 (0.83–2.63), p = 0.1878

Laterality

Right

Reference

N/A

Left

1.13 (0.68–1.87), p = 0.6388

 

Hormone status

HS, no ET

Reference

Reference

HS, received ET

0.37 (0.20–0.69), p = 0.0018

0.33 (0.18–0.61), p = 0.0005

ER−/PR−

0.40 (0.20–0.81), p = 0.0111

0.35 (0.17–0.70), p = 0.0032

Tumor size

≤1 cm

Reference

N/A

>1–2 cm

1.04 (0.60–1.79), p = 0.8894

 

Tumor grade

Grade 1–2

Reference

N/A

Grade 3

1.28 (0.76–2.15), p = 0.3597

 

Unknown

0.86 (0.20–3.64), p = 0.8366

 

Facility type

Other

Reference

Reference

Academic

0.63 (0.34–1.16), p = 0.1404

0.64 (0.34–1.19), p = 0.1604

Unknown

0.00 (0.00-Inf), p = 0.9804

0.00 (0.00-Inf), p = 0.9917

Race/ethnicity

NH-White

Reference

Reference

NH-Black

0.81 (0.32–2.03), p = 0.6543

0.81 (0.32–2.04), p = 0.6560

Hispanic

0.24 (0.03–1.73), p = 0.1565

0.23 (0.03–1.71), p = 0.1527

NH-Other

0.00 (0.00-Inf), p = 0.9829

0.00 (0.00–Inf), p = 0.9887

Unknown

1.37 (0.19–9.94), p = 0.7534

1.47 (0.20–10.86), p = 0.7089

No HSD

<20%

Reference

N/A

≥20%

0.76 (0.43–1.32), p = 0.3213

 

Unknown

0.40 (0.06–2.88), p = 0.3608

 

Income status

≥$46,000/yr

Reference

N/A

<$46,000/yr

1.03 (0.61–1.73), p = 0.9230

 

Unknown

0.44 (0.06–3.27), p = 0.4245

 

Distance to facility

 

N/A

<8.9 miles

Reference

 

≥8.9 miles

0.93 (0.56–1.55), p = 0.7915

 

Chemotherapy

Single-agent

Reference

N/A

Multi-agent

0.99 (0.58–1.69), p = 0.9711

 

Not specified

1.61 (0.38–6.83), p = 0.5216

 
  1. Hazards ratio > 1 implies the factor is associated with increased risk of death.
  2. HR hazards ratio, CI confidence interval, RT radiation therapy, HS hormone-sensitive (ER+ and/or PR+), ET endocrine therapy, NHW non-Hispanic white, NHB non-Hispanic Black, HSD high-school diploma.