Fig. 2: RIPK1 is downregulated in TNBC and associated with enhanced survival. | npj Breast Cancer

Fig. 2: RIPK1 is downregulated in TNBC and associated with enhanced survival.

From: RIPK1 is a negative mediator in Aquaporin 1-driven triple-negative breast carcinoma progression and metastasis

Fig. 2: RIPK1 is downregulated in TNBC and associated with enhanced survival.

A Representative images of anti-RIPK1 immunohistochemistry staining of TNBC and normal breast tissue (×200 magnification). Scale bar: 40 μm. B Quantification of the RIPK1-positive cell percentage in TNBC and normal breast tissue (n = 62). C Representative blotting of Western blot analysis of TNBC and normal breast tissue. Abbreviations: N, normal breast tissue; C, TNBC. D Quantification of relative expression levels of RIPK1, Caspase-8, RIPK3, and phospho-MLKL (p-MLKL) in TNBC and normal breast tissue (n = 62). E Kaplan–Meier survival plot showing the invasive-disease-free survival of TNBC patients in the current cohort stratified by dichotomic expression levels of AQP1 (n = 31 for each group). Note: *p < 0.05, **p < 0.01.

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