Fig. 4: The Phylogenetic tree of tumor samples from patient P6.

The trunk of the tree represents clusters of mutations that are common to both tumor samples, likely representing truncal mutations. The lengths of the trunk and the branches of the tree are proportional to the number of corresponding mutations. Major subclones are labelled in the same color as in Fig. 3b. Gene labels refer to mutations in genes that are identified in T11 only, T12 only, or common to both tumors. The gene labels are nonexhaustive.