Table 1 Three major networks of overlapping differences in GE and CNV in NTUH and METABRIC cohorts.
Network | |||
|---|---|---|---|
Top 1 | Top 2 | Top 3 | |
Age <50 years | |||
ER+/HER2− | NFkB, CCL2, CASP9 | PI3K, Akt, JUN, Jnk, IFNα, H2AFX | ERK1, MAPK, AP1, VEGF, APOA1, APOC3 |
ER−/HER2+ | MAPK, RARA, ERK1/2, Akt, IFNα, Hsp90, histone h3 | MAPK, STAT1, SP1, CDKN1B, RARA, CD40LG, MMP9 | TP53, RELA, NR3C1, |
ER−/HER2− | NFkB, ERK, PI3K, 26 s proteosome | NFkB, BCL2L1, TAC1, Pkc, CALCA | Histone h3, LH, FSH, RNA polymerase II, PDLIM2 |
Age ≥50 years | |||
ER+/HER2− | NFkB, PI3K, INFα, P38MAPK, Jnk | ERK1/2, Akt, CCDC88A, CYP19A1, focal adhesion kinase, Hsp90, JLN1 | MAPK, ERK, Ap1, ER |
ER−/HER2+ | P38MAPK, IFNα, Hsp90, Jnk, RAD51 | ERK, ER, histone h3, RNA polymerase II, cyclin A | NFkB, PKc, PI3K, PTK2B, CD3, TCR, ITGB1, PTK2B, BCL10 |
ER−/HER2− | NFkB, PI3K, ITGB3, MYD88 | STAT3, STAT1, TNF | CTNNB1, TP53, ESR1, CCND1, TGFBR2, EGFR |
