Fig. 6: Immune correlatives in orthotopic mouse models of TNBC treated with TM. | npj Breast Cancer

Fig. 6: Immune correlatives in orthotopic mouse models of TNBC treated with TM.

From: Tetrathiomolybdate (TM)-associated copper depletion influences collagen remodeling and immune response in the pre-metastatic niche of breast cancer

Fig. 6: Immune correlatives in orthotopic mouse models of TNBC treated with TM.The alternative text for this image may have been generated using AI.

Panel (A) depicts the schematic for an orthotopic, lung metastatic mouse model of TNBC, treated with TM vs. controls. Panels (B and C) depict immune and myeloid cell populations from flow cytometry in primary tumor (B) and lung tissue (C), respectively. TM-treated mice had significantly reduced myeloid derived suppressor cells (MDSCs) in primary tumors, as compared to controls. There was a trend towards more NK cells in both tumors and lung tissue of mice treated with TM versus controls. There were no differences in other immune cell populations in the primary tumors or lungs of mice treated with TM vs. Controls. Panel (D) depicts results of immunohistochemistry staining and found that tumor infiltration by CD4+ T cells was significantly higher in TM-treated lungs compared with lungs in the control cohort. p-Values: *p < 0.05, **p < 0.01. All error bars represent standard error of mean (SEM), and all experiments were run in duplicate.

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