Table 1 Characteristics of healthy volunteers and patients with breast cancer.
From: Circulating cell-free DNA-based methylation patterns for breast cancer diagnosis
Characteristics | Subgroup | Whole set (n = 333) | Training set (n = 160) | Validation set (n = 69) | Testing set (n = 104) |
|---|---|---|---|---|---|
Number of samples | Healthy control | 129 | 52 | 22 | 55 |
Patients with BC | 204 | 108 | 47 | 49 | |
Age (patients/healthy) | <40 | 3/6 | 2/0 | 1/0 | 0/6 |
40–49 | 88/59 | 51/30 | 22/11 | 15/18 | |
50–59 | 85/50 | 47/21 | 19/8 | 19/21 | |
≥60 | 28/14 | 8/1 | 5/3 | 15/10 | |
Mean | 51.88/49.4 | 50.4/49.2 | 51.4/49.7 | 55.6/49.3 | |
Subtype | Luminal A | 53 | 30 | 12 | 11 |
Luminal B (HER2+) | 31 | 12 | 7 | 12 | |
Luminal B (HER2−) | 58 | 32 | 16 | 10 | |
HER2 | 15 | 8 | 4 | 3 | |
TNBC | 23 | 13 | 4 | 6 | |
NA (DCIS) | 24 | 13 | 4 | 7 | |
Stage | 0 | 11 | 5 | 3 | 3 |
I | 68 | 40 | 12 | 16 | |
II | 91 | 44 | 22 | 25 | |
III | 32 | 19 | 8 | 5 |
