Fig. 1: ExLR profiles of the cohort.

a, b EVs were detected by transmission electron microscopy (a) and flow cytometry (b). Scale bar, 200 nm. c Western blots of EV markers TSG101 and CD63 expression in peripheral blood mononuclear cells (PBMC) and isolated vesicles. d The distribution of exLRs per sample among BC, benign, and healthy patients. e Heatmap of unsupervised hierarchical clustering of the exLRs that were differentially expressed between BC patients and controls (healthy + benign). Each column represents an individual sample, and each row represents an exLR. The scale represents the expression values. f KEGG pathway enrichment analysis for the differentially expressed exLRs.