Fig. 8: ATF4 overexpression inhibited tumor growth in a CAL-148 cell orthotopic xenograft mouse model. | npj Breast Cancer

Fig. 8: ATF4 overexpression inhibited tumor growth in a CAL-148 cell orthotopic xenograft mouse model.

From: Endoplasmic reticulum stress inhibits AR expression via the PERK/eIF2α/ATF4 pathway in luminal androgen receptor triple-negative breast cancer and prostate cancer

Fig. 8

a Effect of ATF4 overexpression on tumor growth of CAL-148 xenografts. Tumor volume was measured every 3 days and expressed as mean ± SD. Student’s t-test, **p < 0.01 vs. LV-GFP, n = 5. b Representative image of tumors from each group. c Body weight changes in mice during the 21 days (n = 5). d Representative tumor tissues were sectioned and subjected to immunohistochemistry staining (magnification, ×400). scale bar: 50 μM. e Representative tumor tissues from each group were prepared and subjected to western blot assay.

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