Table 1 Baseline demographics and disease characteristics for factors used to create propensity score for matching at diagnosis and 5 years after diagnosis without recurrence within 5 years.

From: Inflammatory cytokines and distant recurrence in HER2-negative early breast cancer

 

Entire population

Parent cohort (at diagnosis)

Late relapse cohort (5 years after diagnosis)

Characteristics

Number (%) of patients

Number (%) of patients

Number (%) of patients

Total number

 Case:control pairs

Not applicable

249

17

 Patients

4994

498

34

Age group (years)

 <40

627 (13)

74 (15)

 40 to <65

3895 (78)

364 (73)

26 (76)

 ≥65

472 (9)

60 (12)

8 (24)

Menopausal status

 Pre/peri

2387 (48)

228 (46)

9 (26)

 Post

2564 (52)

270 (54)

25 (74)

ERPgR status

 ER and PgR negative

1796 (36)

180 (36)

2 (6)

 ER and/or PgR positive

3198 (64)

318 (64)

32 (94)

 Tumor size

 ≤2 cm

1933 (39)

83 (17)

6 (17)

 >2 to ≤5 cm

2552 (51)

334 (67)

23 (68)

 >5 cm

503 (10)

81 (16)

5 (15)

Nodal status

 Negative

1300 (26)

74 (15)

4 (12)

 1–3

2139 (43)

157 (32)

5 (15)

 4+

1555 (31)

267 (53)

25 (74)

Histologic grade

 I

422 (9)

15 (3)

6 (18)

 II

1628 (33)

153 (31)

16 (47)

 III

2833 (58)

330 (66)

12 (35)

Treatmenta

 No bevacizumab

1000 (20)

96 (19)

5 (15)

 Bevacizumab

3994 (80)

402 (81)

29 (85)

  1. aBevacizumab treatment was not a covariate used in propensity score matching; randomization to three arms in E5103 parent trial was 1:2:2 (placebo: bevacizumab × 4 doses; bevacizumab × 14 doses). The characteristics of both the parent cohort and late relapse cohort are those at diagnosis. Data were missing for ER/PR (n = 2) tumor size (n = 6), grade (n = 111), and menopausal status (n = 43, including 20 with male gender; all in case:control sample were female).