Fig. 1: Molecular characterization and classification of (inflammatory) breast cancer cell lines. | npj Breast Cancer

Fig. 1: Molecular characterization and classification of (inflammatory) breast cancer cell lines.

From: Comparative transcriptional analyses of preclinical models and patient samples reveal MYC and RELA driven expression patterns that define the molecular landscape of IBC

Fig. 1

a Dendrogram resulting from an unsupervised hierarchical cluster analysis performed on the normalized expression data set of preclinical models prior to averaging. The different cell lines are indicated using different colors in the annotation track underneath the dendrogram, in addition to the tumor phenotype (blue = nIBC; yellow = IBC), the ER status (gray = ER+; black = ER−), the HER2 status (gray = HER2−; black = HER2+), the PR status (gray = PR+; black = PR−), and the ER/HER2 combined subtypes (red = ER+/HER2−; green = ER−/HER2+; blue = ER+/HER2+; purple = ER−/HER2−). b The classification scores of the preclinical models are shown in boxplot format. The different preclinical models are shown along the X-axis and the Y-axis represents the posterior probability scores resulting from applying the IBC classification models. Boxes are color-coded according to the tumor phenotype: blue = nIBC and yellow = IBC.

Back to article page