Fig. 5: Expression analysis of proximal MYC network members. | npj Breast Cancer

Fig. 5: Expression analysis of proximal MYC network members.

From: Comparative transcriptional analyses of preclinical models and patient samples reveal MYC and RELA driven expression patterns that define the molecular landscape of IBC

Fig. 5

a Heatmap showing the correlation structure of the proximal MYC network members in IBC cell lines. The proximal MYC network members are indicated along both X- and Y-axes and ordered similarly based on the output of a Ward clustering analysis. Correlations are coded according to a blue-red coloring scheme representing negative to positive correlation coefficients respectively. Correlation values are provided in the corresponding cells. b MYC correlation analysis for the proximal MYC network members in a series of 146 IBC patient samples. The proximal MYC network members and strength of the correlation between their expression and MYC mRNA levels are shown along the X- and Y-axis respectively. Each correlation coefficient is indicated by a dot, coded according to a blue-red coloring scheme representing negative to positive correlation coefficients respectively and correlation values are provided inside. Significant values are indicated with a blue diamond. c, d Scatter plots comparing MYC expression (X-axis) and MYC transcriptional activity (Y-axis) calculated according to the gene set published by Muhar et al. in a series of 146 IBC samples. Each sample is represented by a point, which is colored red if the corresponding sample is characterized by MXD3 (c) or NMYC (d) expression values exceeding the 90th percentile. A regression line depicting the linear relationship between MYC expression and transcriptional activity is indicated and results of the Spearman correlation analysis are provided in the top left corner.

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