Fig. 4: Spatial clusters in METABRIC cohort similar to ICGC cohort. | npj Breast Cancer

Fig. 4: Spatial clusters in METABRIC cohort similar to ICGC cohort.

From: Spatial interplay of lymphocytes and fibroblasts in estrogen receptor-positive HER2-negative breast cancer

Fig. 4: Spatial clusters in METABRIC cohort similar to ICGC cohort.The alternative text for this image may have been generated using AI.

a Dendrogram of the hierarchical clustering of the METABRIC cohort (N = 998) with annotated clinical parameters. b Two-dimensional representation of the six measurements that is acquired by applying a UMAP transformation for the ICGC and METABRIC clusters combined. c Heatmap of the cosine similarity of the mutual gene sets between clusters of the ICGC and METABRIC cohort, FDR q-value < 0.25. d The normalized enrichment score (NES) for the hallmarks of cancer gene sets for each of the six spatial clusters in METABRIC (ER+HER2− samples only, N = 630).

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