Fig. 2: Known resistance genes associated with resistance. | npj Breast Cancer

Fig. 2: Known resistance genes associated with resistance.

From: Identification of biomarkers of response to preoperative talazoparib monotherapy in treatment naïve gBRCA+ breast cancers

Fig. 2

a This oncoplot shows the mutations seen across a curated list of genes linked with resistance to PARPi. b The gene expression of members of the shieldin complex are shown on the Y-axis as log2 TPM. Individual patients (dots) are grouped according to RCB response. Mean expressions are shown by red lines. The p-values are calculated from unpaired two-sided Student’s t tests. In the SHLD2 plot, patients predicted to have copy number loss of the gene are labeled.

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