Fig. 4: A stem cell transcriptional program was associated with response.

a The gene expression (log₂ TPM) of CDH1 is shown on the y-axis. Each dot is a tumor, grouped according to the response to talazoparib. The red lines indicate mean expression. The p-values (by unpaired two-sided Student’s t test) are shown for comparisons between patients with pCR vs other patients, as well as a comparison between pCR and RCB-I, and RCB-II and RCB-III. b The gene expression for CDH1 (x-axis; log₂ TPM) and VIM (y-axis; log₂ TPM) are shown for tumors colored by response. c The rows in the heatmap contain the genes in the leading edge of the EMT gene expression signature, and the columns are samples organized according to response. Warm colors indicate high expression of the genes. d The bars in this plot show the significance (as -log₁₀ of the false discovery rate) of the top 20 most significant oncogenic pathway (rows). The dotted red line shows the cutoff for a 5% false discovery rate. e The enrichment plots for the oncogenic pathway that is most significantly associated with response.