Table 3 DE-SN associated with patient overall survival in AA only, W only, or both AA and W.

From: Adaptive stress response genes associated with breast cancer subtypes and survival outcomes reveal race-related differences

 

AA

W

AA and W

Basal

ACSM3, COPZ2, MCM5, POLE2, E2F8, BLM (XIAP pathway); DLL4 (Jag1-Notch pathway); BIRC5 (NFkB pathway)

COPZ2, PLAU, ABAT (XIAP pathway); TREM1 (OSR pathway), CCNE2 (XIAP and OSR pathways)

COPZ2 (XIAP pathway)

Her2

ACSM3, MCM10, GPR137B, CDC45, LIG1, SLC1A4, PLAU, HIST1H2BJ, CDKN2D, CDKN1C, LEF1, SLC14A1 (XIAP pathway); MCM3, CCN3, PTGS2, SCD5, NRG1, NAP1L3, TXNIP (OSR pathway); NUDT1 (Immune pathway)

LIG1, LEF1 (XIAP pathway); CD72 (TGFβ pathway); SCD5, CEBPD (OSR pathway)

LIG1, LEF1 (XIAP pathway); SCD5 (OSR pathway)

LumB

MYCBP2, STAT4 (Immune pathway); LIPG, CDKN1C, KLRC1 (XIAP pathway); FGF2 ABCA6 (OSR pathway)

PLAU, NRN1, ZFPM2 (XIAP pathway); NAP1L3 (OSR pathway); DAB2 (TGFβ pathway)

-

LumA

MCM10, LIG1, FOSB, PIMREG, GINS2, ABAT (XIAP pathway); METTL7A, TP63, MCM4, CDT1, ANXA3 (OSR pathway); MYC, BIRC5 (NFkB pathway); MELK (Immune pathway)

-

-

Normal-like

FOSB (XIAP pathway)

-

-

  1. DE-SN associated with breast cancer patient overall survival among AA patients only, W patients only, or both AA and W patients. The pathway, to which the ASR genes belong, are shown in parentheses and are bolded.
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