Table 4 Previously published associations between TP53 status and overall survival, by estrogen receptor (ER) status and TP53 classification method.
IHC | DNA | RNA | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
Effect of TP53 mut-like | Effect of TP53 mut | Effect of TP53 mut-like | |||||||||
Publication | N cases (TP53 mut-like) | Estimate | Direction | Publication | N cases (TP53 mut) | Estimate | Direction | Publication | N cases (TP53 mut-like) | Estimate | Direction |
Overall | |||||||||||
Rossner38 | 859 (307) | 0.80 (0.47, 1.33)a | X | Shiao41 | 47 (9) | 0.64 (0.07, 5.51) | X | ||||
Coates9 | 1113 (303) | 1.12 (0.89, 1.39) | X | Rossner38 | 859 (128) | 1.04 (0.59, 1.85)a | X | ||||
Yamashita39 | 73 (16) | 2.36 (1.20, 4.67) | ↓↓ | Andersson42 | 370 (105) | 1.33 (0.92, 1.93) | ↓ | ||||
Song4 | 440 (227) | 3.10 (1.02, 9.44) | ↓↓ | Powell5 | 1037 (178) | 1.9 (1.3, 2.8) | ↓↓ | ||||
Iwaya40 | 31 (5) | p < 0.01 | ↓↓ | Pharoah1 | 2319 (539) | 2.0 (1.7, 2.5) | ↓↓ | ||||
Blaszyk6 | 90 (32) | p = 0.0001 | ↓↓ | Silwal-Pandit7 | 1420 (402) | 2.03 (1.65, 2.48)a | ↓↓ | ||||
Olivier43 | 1107 (144) | 2.40 (1.70, 3.38)b | ↓↓ | ||||||||
Dobes2 | 204 (54) | 5.38 (2.14, 13.52) | ↓↓ | ||||||||
Shiao41 | 45 (9) | 5.62 (1.37, 23.00)c | ↓↓ | ||||||||
Bergh44 | 297 (65) | p = 0.02a | ↓↓ | ||||||||
Meric-Bernstam3, | 165 (47) | p = 0.0004 | ↓↓ | ||||||||
Ungerleider45 | 1979 (663) | p < 0.0001 | ↓↓ | ||||||||
ER positive | |||||||||||
Coates9 | 880 (171) | 1.29 (0.98, 1.70) | ↓ | Caleffi21 | 106 (17) | p = 0.37 | X | Coutant10 | 134 (49) | 2.43 (0.96, 6.15) | X |
Feeley20 | 359 (48) | 1.96 (1.00, 3.84) | ↓↓ | Silwal-Pandit7 | 1037 (195) | 1.86 (1.39, 2.49)a | ↓↓ | Coutant10 | 191 (101) | 2.30 (1.25, 423)d | ↓↓ |
ER negative | |||||||||||
Coates9 | 212 (125) | 0.62 (0.40, 0.97) | ↑↑ | Silwal-Pandit7 | 306 (196) | 1.15 (0.77, 1.72)a | X | Coutant10 | 64 (41) | p = 0.27 | X |
Caleffi21 | 86 (26) | p = 0.87 | X | ||||||||