Table 4 Previously published associations between TP53 status and overall survival, by estrogen receptor (ER) status and TP53 classification method.

From: Prognostic significance of RNA-based TP53 pathway function among estrogen receptor positive and negative breast cancer cases

IHC

DNA

RNA

  

Effect of TP53 mut-like

  

Effect of TP53 mut

  

Effect of TP53 mut-like

Publication

N cases (TP53 mut-like)

Estimate

Direction

Publication

N cases (TP53 mut)

Estimate

Direction

Publication

N cases (TP53 mut-like)

Estimate

Direction

Overall

Rossner38

859 (307)

0.80 (0.47, 1.33)a

X

Shiao41

47 (9)

0.64 (0.07, 5.51)

X

    

Coates9

1113 (303)

1.12 (0.89, 1.39)

X

Rossner38

859 (128)

1.04 (0.59, 1.85)a

X

    

Yamashita39

73 (16)

2.36 (1.20, 4.67)

↓↓

Andersson42

370 (105)

1.33 (0.92, 1.93)

    

Song4

440 (227)

3.10 (1.02, 9.44)

↓↓

Powell5

1037 (178)

1.9 (1.3, 2.8)

↓↓

    

Iwaya40

31 (5)

p < 0.01

↓↓

Pharoah1

2319 (539)

2.0 (1.7, 2.5)

↓↓

    

Blaszyk6

90 (32)

p = 0.0001

↓↓

Silwal-Pandit7

1420 (402)

2.03 (1.65, 2.48)a

↓↓

    
    

Olivier43

1107 (144)

2.40 (1.70, 3.38)b

↓↓

    
    

Dobes2

204 (54)

5.38 (2.14, 13.52)

↓↓

    
    

Shiao41

45 (9)

5.62 (1.37, 23.00)c

↓↓

    
    

Bergh44

297 (65)

p = 0.02a

↓↓

    
    

Meric-Bernstam3,

165 (47)

p = 0.0004

↓↓

    
    

Ungerleider45

1979 (663)

p < 0.0001

↓↓

    

ER positive

Coates9

880 (171)

1.29 (0.98, 1.70)

Caleffi21

106 (17)

p = 0.37

X

Coutant10

134 (49)

2.43 (0.96, 6.15)

X

Feeley20

359 (48)

1.96 (1.00, 3.84)

↓↓

Silwal-Pandit7

1037 (195)

1.86 (1.39, 2.49)a

↓↓

Coutant10

191 (101)

2.30 (1.25, 423)d

↓↓

ER negative

Coates9

212 (125)

0.62 (0.40, 0.97)

↑↑

Silwal-Pandit7

306 (196)

1.15 (0.77, 1.72)a

X

Coutant10

64 (41)

p = 0.27

X

    

Caleffi21

86 (26)

p = 0.87

X

    
  1. Double downward arrows represent a significant decreased risk of survival. A single downward arrow represents a non-significant decreased risk of survival. X’s represent a null association with survival. Double upward arrows represent a significant increased risk of survival.
  2. ER estrogen receptor, IHC immunohistochemistry, mut mutant.
  3. aBreast cancer specific survival.
  4. bAmong PR positives.
  5. cAmong Black cases.
  6. dDistant metastasis-free survival.