Fig. 4: Kaplan–Meier curves demonstrating survival rates relative to ST8Sia4 and polysialic acid expression in tumor cells and tumor-infiltrating lymphocytes. | npj Breast Cancer

Fig. 4: Kaplan–Meier curves demonstrating survival rates relative to ST8Sia4 and polysialic acid expression in tumor cells and tumor-infiltrating lymphocytes.

From: The different prognostic significance of polysialic acid and CD56 expression in tumor cells and lymphocytes identified in breast cancer

Fig. 4: Kaplan–Meier curves demonstrating survival rates relative to ST8Sia4 and polysialic acid expression in tumor cells and tumor-infiltrating lymphocytes.The alternative text for this image may have been generated using AI.

A Overall survival of individuals based on ST8Sia4 expression in tumor cells. Patients were categorized as either ST8Sia4 high (>1.25 RNA punctae/cell) or low ST8Sia4 (≤1.25 RNA puncate/cell). B Animated diagram depicting the prognostic significance of ST8Sia4 expression in tumor cells. C Overall survival of individuals based on polysialic acid levels in tumor cells. Patients were categorized as high expression (H-Score > 0.66) or moderate/low (H-Score ≤ 0.66). High ST8Sia4 and polySia cut-point value was set at the 75% Percentile ±SEM of all values. Overall Survival curve comparison: Log-rank (Mantel–Cox) test. D Overall survival of individuals based on infiltrating stromal cell ST8Sia4 expression in TIL-positive tumor cores. Patients were categorized as either ST8Sia4 high (>0.4 RNA punctae/cell) or low ST8Sia4 (≤0.4 RNA punctae/cell). High ST8Sia4 cut-point value was set at the median ± SEM of all values. E Animated diagram depicting the prognostic significance of ST8Sia4 expression in infiltrating stromal cells. F Overall survival of individuals based on polysialic acid levels on TIL. Patients were categorized as high expression (H-Score > 0.55) or moderate/low (H-Score ≤ 0.55). TIL Negative (tumor cores absent for TIL). High polySia cut-point value was set at the 75% Percentile ±SEM of all values. Overall Survival curve comparison: Log-rank (Mantel–Cox) test.

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