Fig. 5: The GSEA and GSVA results of GPER correlated pathways based on the transcriptomic data of 360 TNBC patients. | npj Breast Cancer

Fig. 5: The GSEA and GSVA results of GPER correlated pathways based on the transcriptomic data of 360 TNBC patients.

From: High GPER expression in triple-negative breast cancer is linked to pro-metastatic pathways and predicts poor patient outcomes

Fig. 5: The GSEA and GSVA results of GPER correlated pathways based on the transcriptomic data of 360 TNBC patients.

a Dotplot showing the twelve most significantly upregulated pathways in GPER-high and GPER-low groups from GSEA results. In the group of high GPER expression, seven of the twelve upregulated pathways are correlated with promoting tumor metastasis. b GSEA-plots showing the upregulated pro-metastatic pathways in the GPER-high group. c Heatmap for the eight most significantly upregulated pathways in GPER-high group by GSVA. Statistically significant differences were defined as adjusted P-value < 0.05.

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