Fig. 5: Correlation of mitotic count and Ki-67 expression.
From: Deep learning models for histologic grading of breast cancer and association with disease prognosis
Correlation of mitotic count and Ki-67 gene expression is shown for the mitotic count provided by the DLS (A) and by pathologist review (B). Values in brackets below plots represent 95% confidence interval for correlation. Box plot box edges and center line indicate quartiles (25th, 50th, and 75th percentile) of Ki-67 gene expression (TPM values via TCGA) for each MC score, with outliers (defined as values beyond 1.5 times the interquartile range) plotted as black circles. The correlation values for DLS MC scoring with Ki-67 (0.47) and pathologist MC scoring with Ki-67 (0.37) were significantly different (p = 0.002; permutation test) based on a permutation test with n = 1000 samples. DLS deep learning system, MC Mitotic Count.
