Fig. 1: Comparison of the number of somatic alterations and medium maximum MAF in MSI-H versus non-MSI-H samples.

a Distribution of the number of somatic alterations detected per sample, including synonymous variants and variants of uncertain significance, excluding amplifications, in MSI-H versus non-MSI-H samples. The number of somatic alterations in individual samples is represented by colored dots with median value and interquartile range outlined in black. b Median maximum MAF in MSI-H versus non-MSI-H samples (Mann–Whitney U-test p < 0.0001).