Fig. 4: Analysis of pre-specified mechanism-of-action gene expression biomarkers for ganetespib response. | npj Breast Cancer

Fig. 4: Analysis of pre-specified mechanism-of-action gene expression biomarkers for ganetespib response.

From: Safety and efficacy of HSP90 inhibitor ganetespib for neoadjuvant treatment of stage II/III breast cancer

Fig. 4

Association dot-plot showing the level and direction of association between each gene (row) and pCR in the population/model as labeled (columns from right to left): G arm, control arm, interaction with treatment, interaction with treatment in a model adjusting for HR status; and analysis limited to the TN and HR+HER2- subsets. Key = red/blue dot indicates higher/lower levels ~ pCR; size of dot ~ strength of association (1/p likelihood ratio test), with dark outline/white background indicating p < 0.05 (likelihood ratio test) and gray background indicating p > 0.05 (likelihood ratio test). All biomarkers were assessed at the pre-treatment time point.

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