Table 3 Sub analysis of select endocrine-related symptoms reported in the first 5 years post-diagnosis among extended endocrine therapy users and non-usersa.

From: Extended adjuvant endocrine therapy in a longitudinal cohort of young breast cancer survivors

BCPT symptom scale

Mean (SD) score

Not bothered (score = 0)

Extremely bothered (score = 3.5–4)

Total (n = 450)

eET users (n = 288)

eET non-users (n = 162)

P

eET users (n = 288)

eET non-users (n = 162)

P

eET users (n = 288)

eET non-users (n = 162)

P

Weight problems

1.00 (0.97)

0.97 (0.93)

1.07 (1.04)

0.267

68 (23.6%)

43 (26.5%)

0.489

9 (3.1%)

6 (3.7%)

0.743

Vaginal problems

1.06 (1.21)

1.12 (1.23)

0.95 (1.17)

0.168

104 (36.1%)

69 (42.6%)

0.175

24 (8.3%)

11 (6.8%)

0.557

Muscle problems

1.03 (1.00)

1.04 (1.01)

1.01 (0.98)

0.811

69 (24.0%)

41 (25.3%)

0.749

10 (3.5%)

5 (3.1%)

0.827

Hot flashes

1.22 (1.16)

1.30 (1.19)

1.07 (1.09)

0.050

71 (24.7%)

52 (32.1%)

0.089

22 (7.6%)

6 (3.7%)

0.097

  1. Analysis restricted to participants who reported any ET use in the first 5 years post-diagnosis. P values were calculated by Student’s t-test for means and Chi-Square test for percentages.
  2. BCPT breast cancer prevention trial, SD standard deviation, eET extended endocrine therapy.